PPS Fatigue and NADH
Eddie Bollenbach

From a Post to the Post-Polio-Med Email List With Permission

Eddie Bollenbach Bio & Picture

Date: Fri, 19 Mar 1999 14:00:40 -0500
From: "Eddie Bollenbach"
Subject: Re: [PPM] NADH

When I saw the article which demonstrated that NADH can have a positive effect on fatigue it really didn't come as a big surprise. The reason for this is NAD (without H=Hydrogen atom) is the first molecule that grabs hydrogen atoms from food molecules, like glucose, during cellular energy production. In doing so NAD becomes NADH and then has the ability to separate the hydrogen atom from its orbiting electron---which is shuttled through electron acceptor molecules eventually to oxygen. All this takes place inside the Cell in a place in there called a mitochondrion. To make a long obtuse story short NADH is involved in the production of useful energy by cells---both muscle and nerve cells-- and this has been studied by college biology students for decades.

So, if the amount of NADH available limits how much energy can be produced -- which means, as an ingredient in the series of reactions of energy production it is in shorter than optimal supply, then it should work. Since it does means if we increase its concentration we speed cellular energy production. NAD is a cousin to Nicotinic acid. The complete name is Nicotinamide Adenine Dinucleotide. With H on it it is said to be in its "reduced " form. When it is reduced it is primed to pass those electrons and hydrogens to other acceptors releasing energy at each step and pumping Hydrogen ions H (an atom without an electron) out across membranes creating a small voltage in the process (more positive outside the membrane with the H ). This provides functional energy for nerve and muscle cells.

NADH is at the heart of our understanding of energy production at the level of the cell. It probably won't work for everyone though, particularly if NAD is not limiting.

Worth a try, I think

Editor's Note: From a follow up post by Eddie:
Below is extracted a news item from an FDA approved study of the use of NADH for Chronic Fatigue. These are Georgetown scientists speaking of an FDA approved trial. It contradicts the other writer:

"The study found NADH never caused any adverse effects. The preliminary results of this ongoing study suggest that 6 of 23 (26%) patients responded to the NADH and showed a marked improvement in physical, psychological, and neurocognitive measures. Significantly, 8 of 11 (73%) study patients enrolled in a longer, open label follow-up study showed significant improvement in clinical symptomatology and energy levels"

...... Eddie
Contact Professor Edward P. Bollenbach
Academic Web Pages: Home: http://www.angelfire.com/mi/nccc/
Microbiology: http://www.angelfire.com/mi/nccc/mine.html
Chemistry: http://www.angelfire.com/mi/nccc/chem.html

Added NOTES: Additional NADH resources: [*=commercial site selling supplements]