Date: Wed, 19 Jul 2000 10:42:47 -0400
From: "Eddie Bollenbach" <edward.bollenbach
Subject: [PPM] Research
From my vantage point some of the research on PPS by Dalakas at NIH is illuminating. At least it shows clearly how late muscle weakness in PPS occurs with some rather clear electron micrographs. The why is a tougher nut to crack. Do neurons lose end fibers to muscles in PPS because the NERVES have been overused? Or do the end fibers break free of hypertrophied fibers because the MUSCLE FIBERS have been overused and cannot support synapse with the neurons? Is the inflammation found in the spinal cord the primary cause for morbid neurons in PPS? Is the inflammation in the cord due to tissue disintegration or persistent viral protein antigens?
We've been working on finding molecular causes for cancer, auto immune disease, mental illness, and a host of human health problems for decades. I don't think the illusive nature of a clear answer to PPS will be any easier than a lot of these other biological problems. Some of the research will turn out wrong and some will turn out close to the truth. That's the way science works. Right now we need to attract high quality people to do the research. Many of these people are interested in "more sexy" problems like AIDS and Spinal Cord injury. Frankly, I don't know how to get the money to flow and the interest to grow for late polio problems as we enter this next century.
FYI --- any publications I have done were done out of an intense interest in the problem. I have never been paid for any of them and didn't need to do any of them to get promoted or keep a job. It was just a lot of work and, hopefully, helped some of my own.
Contact Professor Edward P. Bollenbach
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